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Pregnancy: Fluorouracil may be mutagenic and must not be used during pregnancy. Women of childbearing age should ensure effective contraception during treatment with fluorouracil and up to 6 months afterwards. If pregnancy occurs during treatment, the possibility of genetic counseling is to be exploited.
Lactation: Fluorouracil must not be used during the lactation period.
Fertility: Fluorouracil can be genetically harmful. Men treated with fluorouracil are therefore recommended not to father a child during treatment as well as up to 6 months afterwards.
Advice on conservation of sperm should be sought prior to treatment because of the possibility of serious disturbances of spermatogenesis due to therapy with Fluorouracil.
